Greetings! I’m curious if any of you are preparing cisapride (Propulsid
™) suspensions. If so, would you share your formula with me. Also,
what is the stability of the finished product. I have been told that no
more than a seven day supply you be dispensed. Is there any data to
support this?
Thanks.
Steve Newton (S C New…@aol.com)
In article <34sj4k$…@search01.news.aol.com> scnew…@aol.com (S C Newton) writes:
>Greetings! I’m curious if any of you are preparing cisapride (Propulsid
>(tm)) suspensions. If so, would you share your formula with me. Also,
>what is the stability of the finished product. I have been told that no
>more than a seven day supply you be dispensed. Is there any data to
>support this?
Cisapride Oral Suspension
per Janssen Pharmaceuticals
Final concentration is 1 mg/mL
Compound: Pulverize five 10 mg tablets of cisapride anf levigate with a
small amount of distilled water. Add 25 mL of Ora-Plus (a suspending
vehicle) in small increments until uniformly mixed. Add this mixture to a
bottle and qs to 50 mL with Ora-Sweet.
It is very important to add the Ora-Plus first and make sure that half the
total volume is Ora-Plus. It is acceptable if the Ora-Sweet volume is less
than half.
If solution is refrigerated it expires in 14 days.
—————————————————————————–
Joseph J. Rivest "Lilrascal"
email: ras…@csd4.csd.uwm.edu I’ll never get out of this place!
snail mail: 4240 N. Main St #302 University Wisconsin-Milwaukee
Racine, WI 53402
—————————————————————————–
I read your post concerning cisapride suspension. the company does now
make a suspension. you shouldn’t need to make it. check with your
wholesaler.
maddie
In article <34uspa$…@search01.news.aol.com>, meadhb…@aol.com
(Meadhbhni) writes:
>I read your post concerning cisapride suspension. the company does now
>make a suspension. you shouldn’t need to make it. check with your
>wholesaler.
>maddie
Dear Maddie – Janssen has not yet released Propulsid suspension. Possibly
early 1995.
Dave
in an article daver…@aol.com wrote about Re: Cisapride Suspension Compounding
Moin!
> Dear Maddie – Janssen has not yet released Propulsid suspension. Possibly
> early 1995.
> Dave
Its available in germany since 2 years…
slan /2.11
Peter
————————————————————————–
peter froese apo…@nord.toppoint.de
gerhardstr. 3 2:240/2…@fidonet.org
24768 rendsburg 232:23…@aponet.ftn <<the pharmacists network>>
————————————————————————–
## CrossPoint v3.02 ##
peter froese (apo…@nord.toppoint.de) wrote:
: in an article daver…@aol.com wrote about Re: Cisapride Suspension Compounding
: Moin!
: > Dear Maddie – Janssen has not yet released Propulsid suspension. Possibly
: > early 1995.
: > Dave
: Its available in germany since 2 years…
In the mean time, does anyone have a good method of compounding cisapride
tablets into a suspension. Also if you have any stability data, it would
be appreciated.
–
RRRRRRRR PPPPPPPP
RR RR PP PP
RR RR PP PP *******************
RR RR PP PP *rob…@cloud9.net*
RR RR PP *******************
RR RR PP
RR RR RR
Robert- I called Janssen on their 1-800-526-7736 number. I would suggest
that you do the same. They will FAX you (or) MAIL to you a formula that they
have. It seems that this particular formula cannot be sanctioned by Janssen
since they didn’t compose it. However, it is reliable, and has been
published elsewhere..so they say… I have been compounding with cherry
syrup, BUT, with JUST the cherry syrup, 50% of the drug is lost by day # 5.
There formula (the one they will fax to you) has proplyene glycol which
increased the stability..Sorry, I don’t have the formula with me here at
home, but the phone #’s there for you to use. Hope this helps,
, _
(_) Russ Newton
_______// South Elgin, Il
(________)
\ / Newt…@Delphi.com
| Rx |
/______\
(________)
In article <5_dcEspC…@nord.toppoint.de>, apo…@nord.toppoint.de (peter
froese) writes:
> Its available in germany since 2 years…
Sorry I wasn’t clear, Peter – In the U.S. it has not been released yet.
Dave
In article <34sbmh$…@search01.news.aol.com>, barba…@aol.com (Barbara6) writes:
|> In article <34qutd$…@herald.indirect.com>, e…@indirect.com (Ed Snible)
|> writes:
|>
|> Is it safe to quit antibiotics?
|> The answer is an emphatic "NO". The pharmacist you talked to is right.
<<<reply shortened>>> P.S. Lose the Doctor.
|> barbara
I whole-heartedly second Barbara’s opinion! Bacteria are likely to develop resistance if you do not kill them all off the first time they encounter an antibiotic. Classic example: Good old penicillin V potassium, it was a wonder drug in the 50′s, 60′s and 70′s and then it started to decline in its usefulness due to resistance. Now we’re lucky if it can still take out 1 in 10 community acquired Strep or Staph infections.
If the antibiotic is working, you’ll likely feel better within a couple of days but there are still millions of bugs left alive and it takes more time for your immune system and the meds to knock ‘em all dead. Many doctors in my area of Michigan feel that 7-10 days of meds are not enough. From now until May of ’95 we’ll start to see more ‘scripts written for a 14-21 day supply as the cold & flu season starts playing tag-team wrestling with everyone’s sinuses.
Speaking of sinuses and other knooks and crannies that bugs can hide out in effectively and survive antibiotic attack, often a "cure" is really just a temporary victory forcing the bugs to retreat to a point where the body no longer experiences the agonies associated with infection and our immune reaction (inflammed air passages, fever, pressure induced pain, etc. etc.). It’s especially important to take all the antibiotics if the infection is in a place with many hiding places that do not get a really great blood supply to deliver the drugs to in the first place (tonsils, sinuses, middle ear).
Remember, all it takes is one bug to live through it. They don’t like being lonely and they’ll soon make some company to enjoy. I know this sounds flip, but hey, it’s Saturday. I just listened to a thrilling upset victory over Notre-Dame by the Maize & Blue and I decided to go surfing instead of get work done on my thesis.
Good answer, Barbara! Cheers,
Peter
Ed Snible (e…@indirect.com) wrote:
: edited out …
: I have no way to even start researching this, does anyone know if this
: guy is ahead of common medical knowledge or a quack? I asked another
: pharmacist and he said that there was a big danger of either relapse of
: my ear infection or that when I got old my body wouldn’t be able to fight
: off diseases if I stopped taking the antibiotics, and my curiosity is
: aroused.
Listen to your pharmacist! The purpose of finishing your antibiotics is to
ensure that all the microbes in your system is wiped out completely. Even if
you feel better after a few days, there is a good chance of residual levels
of microbes. These residual levels of microbes could multiply to cause a
recurrence of disease if the antibiotics are not continued. I would think
twice about going back to this "doc" …
Andrew
In article <34qutd$…@herald.indirect.com>, e…@indirect.com (Ed Snible)
writes:
Is it safe to quit antibiotics?
The answer is an emphatic "NO". The pharmacist you talked to is right.
When you stop taking antibiotic you can get an overgrowth of resistant
bacteria. You must keep taking all of your antibiotic even if you feel
better. P.S. Lose the Doctor.
barbara
barba…@aol.com (Barbara6) writes:
>In article <34qutd$…@herald.indirect.com>, e…@indirect.com (Ed Snible)
>writes:
>Is it safe to quit antibiotics?
>The answer is an emphatic "NO". The pharmacist you talked to is right.
>When you stop taking antibiotic you can get an overgrowth of resistant
>bacteria. You must keep taking all of your antibiotic even if you feel
>better. P.S. Lose the Doctor.
>barbara
I’d like to add an even greater stress to Barbara’s reply.
When she talks about "resistant bacteria", she brings up what I feel is
one of the most significant factors in pharmacology: that there is, in
this mechanism, a way in which your drug use can hurt others, by adding
more resistant bacteria to the common pool. Antibiotics are the only
drugs for which I believe a credible case for government control of
access can be made.
Again: to d/c antibiotics in mid-course can be dangerous not just to you,
but to all of us.
–
— |"It won’t do to have truth and justice on our side – we
pe…@crl.com | must have law and lawyers." — Bleak House
- Hide quoted text — Show quoted text -
In article <34qutd$…@herald.indirect.com> e…@indirect.com (Ed Snible) writes:
>Ok, so my doc gives me a prescription for Amoxicillian (which ended up
>not fixing my ear) and he says "Take these until you feel better, and
>save the rest for next time you get sick."
>I said, "Uh, doc, I thought I would get in big trouble if I stopped
>taking antibiotics in the middle of their cycle, that is what my dentist
>and pharmacist said…", to which he replied "No, the diseases that can
>kill you if you stop taking antibotics in the middle are extinct except
>in Salt Lake City, Utah and parts of Ohio."
>I have no way to even start researching this, does anyone know if this
>guy is ahead of common medical knowledge or a quack? I asked another
>pharmacist and he said that there was a big danger of either relapse of
>my ear infection or that when I got old my body wouldn’t be able to fight
>off diseases if I stopped taking the antibiotics, and my curiosity is
>aroused.
I’d find another doctor. Soon.
-Rich Young
(The view expressed herein may not reflect that of Eastman Kodak Company, Inc.)
Hi –
I can not understand your physician’s rational for prescribing
amoxicillin for an ear infection and advising you to stop when you feel
beter! The course of therapy must be completed (usually 10 days) to
make sure the infection does not reoccur. A subclinical infection would
probably persist from several days of therapy and may will mainifest
shortly later as a full clinical outbreak. Then you would reappear in
the clinic for another evaluation. Also of concern is that the
microorganisms have the opportunity to become resistant to the
amoxicillin. Self-medication with the amoxicillin that you did not take
because you felt better would probably not be effective.
.
Jonathan Buth