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	<title>Comments on: Nicotine in Cigarettes &#8211; Day One</title>
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		<title>By: admin</title>
		<link>http://www.practiceofpharmacy.com/nicotine-in-cigarettes-day-one/comment-page-1#comment-787</link>
		<dc:creator>admin</dc:creator>
		<pubDate>Wed, 14 Oct 2009 22:51:01 +0000</pubDate>
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  &lt;p&gt;In article &lt;124303Z30031...@anon.penet.fi&gt; an75...@anon.penet.fi writes: &lt;br /&gt; &lt;/p&gt;&lt;p&gt;&gt;Whoever&#039;s comparing caffeine in coffee, etc. with nicotine needs his head &lt;br /&gt; &gt;examined. &#160;The addiction to nicotine helps keep you smoking. &#160;Lung cancer &lt;br /&gt; &gt;is forty times more likely in smokers than non-smokers. &#160;Caffeine in coffee or soft drinks may keep you drinking. &#160;But cancer and other diseases have not shown &lt;br /&gt; &gt;any correlation with caffeine. &#160;The analogy just isn&#039;t there. &lt;br /&gt; &lt;/p&gt;&lt;p&gt;&gt;Abby &lt;br /&gt; &lt;br /&gt;There *is* a similar analogy with caffeine/coffee. Coffee contains oils which &lt;br /&gt; are suspected in aggrivating coronary artery plaque buildup. Caffeine itself &lt;br /&gt; even in soft drink dosage levels is not that good for folks with a genetic &lt;br /&gt; predisposition for hypertension. &lt;br /&gt;
  
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		<content:encoded><![CDATA[<p>In article &lt;124303Z30031&#8230;@anon.penet.fi&gt; <a href="mailto:an75...@anon.penet.fi">an75&#8230;@anon.penet.fi</a> writes:  </p>
<p>&gt;Whoever&#8217;s comparing caffeine in coffee, etc. with nicotine needs his head <br /> &gt;examined. &nbsp;The addiction to nicotine helps keep you smoking. &nbsp;Lung cancer <br /> &gt;is forty times more likely in smokers than non-smokers. &nbsp;Caffeine in coffee or soft drinks may keep you drinking. &nbsp;But cancer and other diseases have not shown <br /> &gt;any correlation with caffeine. &nbsp;The analogy just isn&#8217;t there.  </p>
<p>&gt;Abby </p>
<p>There *is* a similar analogy with caffeine/coffee. Coffee contains oils which <br /> are suspected in aggrivating coronary artery plaque buildup. Caffeine itself <br /> even in soft drink dosage levels is not that good for folks with a genetic <br /> predisposition for hypertension. </p>
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		<title>By: admin</title>
		<link>http://www.practiceofpharmacy.com/nicotine-in-cigarettes-day-one/comment-page-1#comment-786</link>
		<dc:creator>admin</dc:creator>
		<pubDate>Wed, 14 Oct 2009 22:50:56 +0000</pubDate>
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  &lt;p&gt;Bob Michael &lt;cmra...@nt.com&gt; writes: &lt;br /&gt; &gt;The major harm from cigarettes is from the carcinogenic compounds and &lt;br /&gt; &gt;carbon monoxide they contain, not the nicotine. &#160;Ironically, spiking &lt;br /&gt; &gt;cigarettes with nicotine may make them safer because smokers would have &lt;br /&gt; &gt;to ingest fewer carcinogens to satisfy their nicotine dependence. &#160;But I &lt;br /&gt; &gt;think this anti-dependency approach is going in the wrong direction. &#160;If &lt;br /&gt; &gt;we could devise a non-carcinogenic and pleasuable delivery system for &lt;br /&gt; &gt;nicotine, I believe we could live with millions of nicotine addicts. &lt;br /&gt; &gt;It&#039;s the cancer and heart disease that&#039;s costing us money. &lt;br /&gt; &lt;br /&gt;That would be nicotine-fortified chewing gum, wouldn&#039;t it? &#160;I bet that &lt;br /&gt; this form of delivery would not be as satisfying for the user, because &lt;br /&gt; the drug would enter the bloodstream relatively slowly, in comparison &lt;br /&gt; with smoking it. &#160;Smoking tobacco (or any drug) gives the user &lt;br /&gt; nearly instant gratification, which reinforces the habit. &lt;br /&gt; &lt;/p&gt;&lt;p&gt;Jake. &lt;br /&gt; &lt;/p&gt;&lt;p&gt;-- &lt;br /&gt; Whoever achieves understanding of the baboon will do more for metaphysics &lt;br /&gt; than Locke did, which is to say he will do more for philosophy in general, &lt;br /&gt; including the problem of knowlege. &lt;br /&gt; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &lt;-- Charles Darwin &lt;br /&gt;
  
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		<content:encoded><![CDATA[<p>Bob Michael &lt;cmra&#8230;@nt.com&gt; writes: <br /> &gt;The major harm from cigarettes is from the carcinogenic compounds and <br /> &gt;carbon monoxide they contain, not the nicotine. &nbsp;Ironically, spiking <br /> &gt;cigarettes with nicotine may make them safer because smokers would have <br /> &gt;to ingest fewer carcinogens to satisfy their nicotine dependence. &nbsp;But I <br /> &gt;think this anti-dependency approach is going in the wrong direction. &nbsp;If <br /> &gt;we could devise a non-carcinogenic and pleasuable delivery system for <br /> &gt;nicotine, I believe we could live with millions of nicotine addicts. <br /> &gt;It&#8217;s the cancer and heart disease that&#8217;s costing us money. </p>
<p>That would be nicotine-fortified chewing gum, wouldn&#8217;t it? &nbsp;I bet that <br /> this form of delivery would not be as satisfying for the user, because <br /> the drug would enter the bloodstream relatively slowly, in comparison <br /> with smoking it. &nbsp;Smoking tobacco (or any drug) gives the user <br /> nearly instant gratification, which reinforces the habit.  </p>
<p>Jake.  </p>
<p>&#8211; <br /> Whoever achieves understanding of the baboon will do more for metaphysics <br /> than Locke did, which is to say he will do more for philosophy in general, <br /> including the problem of knowlege. <br /> &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &lt;&#8211; Charles Darwin </p>
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		<title>By: admin</title>
		<link>http://www.practiceofpharmacy.com/nicotine-in-cigarettes-day-one/comment-page-1#comment-785</link>
		<dc:creator>admin</dc:creator>
		<pubDate>Wed, 14 Oct 2009 22:50:54 +0000</pubDate>
		<guid isPermaLink="false">http://www.practiceofpharmacy.com/nicotine-in-cigarettes-day-one#comment-785</guid>
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  &lt;p&gt;In article &lt;2n9f4a$...@bmerha64.bnr.ca&gt;, Bob Michael &lt;cmra...@nt.com&gt; writes... &lt;br /&gt; &gt;In article &lt;29MAR199409115...@watson.bms.com&gt; Swamy Yeleswaram, &lt;br /&gt; &gt;yeleswa...@watson.bms.com writes: &lt;br /&gt; &gt;The major harm from cigarettes is from the carcinogenic compounds and &lt;br /&gt; &gt;carbon monoxide they contain, not the nicotine. &lt;br /&gt; &lt;br /&gt;&#160;I am not so sure; For one, the body of literature available for &quot;other &lt;br /&gt; constituents&quot; is no comparison to that on nicotine. &#160;And these studies show &lt;br /&gt; significant and positive correlations between nicotine and various &lt;br /&gt; pathological endpoints. &#160;So it is obvious that nicotine is definitely not an &lt;br /&gt; &quot;innocent bystander&quot; as far as I understand. &#160;Hence, &quot;nicotine-only &lt;br /&gt; cigarettes&quot; were never attempted (not that it wont be popular :-). &lt;br /&gt; &lt;/p&gt;&lt;p&gt;Swamy Yeleswaram, Ph.D. &lt;br /&gt;
  
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		<content:encoded><![CDATA[<p>In article &lt;2n9f4a$&#8230;@bmerha64.bnr.ca&gt;, Bob Michael &lt;cmra&#8230;@nt.com&gt; writes&#8230; <br /> &gt;In article &lt;29MAR199409115&#8230;@watson.bms.com&gt; Swamy Yeleswaram, <br /> &gt;yeleswa&#8230;@watson.bms.com writes: <br /> &gt;The major harm from cigarettes is from the carcinogenic compounds and <br /> &gt;carbon monoxide they contain, not the nicotine. </p>
<p>&nbsp;I am not so sure; For one, the body of literature available for &quot;other <br /> constituents&quot; is no comparison to that on nicotine. &nbsp;And these studies show <br /> significant and positive correlations between nicotine and various <br /> pathological endpoints. &nbsp;So it is obvious that nicotine is definitely not an <br /> &quot;innocent bystander&quot; as far as I understand. &nbsp;Hence, &quot;nicotine-only <br /> cigarettes&quot; were never attempted (not that it wont be popular <img src='http://www.practiceofpharmacy.com/wp-includes/images/smilies/icon_smile.gif' alt=':-)' class='wp-smiley' /> .  </p>
<p>Swamy Yeleswaram, Ph.D. </p>
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		<title>By: admin</title>
		<link>http://www.practiceofpharmacy.com/nicotine-in-cigarettes-day-one/comment-page-1#comment-784</link>
		<dc:creator>admin</dc:creator>
		<pubDate>Wed, 14 Oct 2009 22:50:49 +0000</pubDate>
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  In article &lt;29MAR199409115...@watson.bms.com&gt; Swamy Yeleswaram, &lt;br /&gt; &lt;p&gt;&lt;/p&gt;&lt;p&gt;- Hide quoted text -- Show quoted text -&lt;/p&gt;yeleswa...@watson.bms.com writes: &lt;br /&gt; &gt; I was watching &quot;Day One&quot;, an investigative reporting program by ABC. &lt;br /&gt; They &lt;br /&gt; &gt; talked about cigarette manufacturers &quot;spiking&quot; nicotine to cigarettes &lt;br /&gt; to make &lt;br /&gt; &gt; them addictive. &#160;They also showed FDA&#039;s David Kessler talking to some &lt;br /&gt; House &lt;br /&gt; &gt; committee members about this. &#160;Essentially he was trying to make a case &lt;br /&gt; for &lt;br /&gt; &gt; regulating cigarettes under the purview of &quot;drugs&quot; and he went on to &lt;br /&gt; say that &lt;br /&gt; &gt; cigarettes of today are nothing but sophisticated nicotine delivery &lt;br /&gt; systems &lt;br /&gt; &gt; and since nicotine is addictive, it has to be regulated. &lt;br /&gt; &gt; Since the impetus for this discussion came from suspected &quot;nicotine &lt;br /&gt; &gt; titration&quot;, I couldnt help extrapolating the scenario. &lt;br /&gt; &lt;br /&gt;The major harm from cigarettes is from the carcinogenic compounds and &lt;br /&gt; carbon monoxide they contain, not the nicotine. &#160;Ironically, spiking &lt;br /&gt; cigarettes with nicotine may make them safer because smokers would have &lt;br /&gt; to ingest fewer carcinogens to satisfy their nicotine dependence. &#160;But I &lt;br /&gt; think this anti-dependency approach is going in the wrong direction. &#160;If &lt;br /&gt; we could devise a non-carcinogenic and pleasuable delivery system for &lt;br /&gt; nicotine, I believe we could live with millions of nicotine addicts. &lt;br /&gt; It&#039;s the cancer and heart disease that&#039;s costing us money. &lt;br /&gt;
  
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		<content:encoded><![CDATA[<p>In article &lt;29MAR199409115&#8230;@watson.bms.com&gt; Swamy Yeleswaram, <br /> 
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<p>- Hide quoted text &#8212; Show quoted text -</p>
<p><a href="mailto:yeleswa...@watson.bms.com">yeleswa&#8230;@watson.bms.com</a> writes: <br /> &gt; I was watching &quot;Day One&quot;, an investigative reporting program by ABC. <br /> They <br /> &gt; talked about cigarette manufacturers &quot;spiking&quot; nicotine to cigarettes <br /> to make <br /> &gt; them addictive. &nbsp;They also showed FDA&#8217;s David Kessler talking to some <br /> House <br /> &gt; committee members about this. &nbsp;Essentially he was trying to make a case <br /> for <br /> &gt; regulating cigarettes under the purview of &quot;drugs&quot; and he went on to <br /> say that <br /> &gt; cigarettes of today are nothing but sophisticated nicotine delivery <br /> systems <br /> &gt; and since nicotine is addictive, it has to be regulated. <br /> &gt; Since the impetus for this discussion came from suspected &quot;nicotine <br /> &gt; titration&quot;, I couldnt help extrapolating the scenario. </p>
<p>The major harm from cigarettes is from the carcinogenic compounds and <br /> carbon monoxide they contain, not the nicotine. &nbsp;Ironically, spiking <br /> cigarettes with nicotine may make them safer because smokers would have <br /> to ingest fewer carcinogens to satisfy their nicotine dependence. &nbsp;But I <br /> think this anti-dependency approach is going in the wrong direction. &nbsp;If <br /> we could devise a non-carcinogenic and pleasuable delivery system for <br /> nicotine, I believe we could live with millions of nicotine addicts. <br /> It&#8217;s the cancer and heart disease that&#8217;s costing us money. </p>
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