Comments on: Request information on Toradol http://www.practiceofpharmacy.com/request-information-on-toradol Thu, 29 Jul 2010 10:52:42 +0000 hourly 1 http://wordpress.org/?v=3.0 By: admin http://www.practiceofpharmacy.com/request-information-on-toradol/comment-page-1#comment-5 admin Thu, 13 Aug 2009 17:28:59 +0000 http://www.practiceofpharmacy.com/request-information-on-toradol#comment-5 Here is a user report: I got some Toradol pills after some fairly <br /> complex gum surgery.  Three a day during the first 24 h were <br /> completely effective, with no sedation - a big win over codeine, which <br /> I used during similar occasion, in the past.  After a day I switched <br /> to Ibuprofen.  Toradol is ridiculously expensive compared to codeine <br /> (or Ibuprofen) though: $1.50 / pill, but of course in the noise <br /> relative to the cost of the surgery. <br /> <p>Andrei <br /> </p> Here is a user report: I got some Toradol pills after some fairly
complex gum surgery.  Three a day during the first 24 h were
completely effective, with no sedation – a big win over codeine, which
I used during similar occasion, in the past.  After a day I switched
to Ibuprofen.  Toradol is ridiculously expensive compared to codeine
(or Ibuprofen) though: $1.50 / pill, but of course in the noise
relative to the cost of the surgery.

Andrei

]]> By: admin http://www.practiceofpharmacy.com/request-information-on-toradol/comment-page-1#comment-4 admin Thu, 13 Aug 2009 17:28:57 +0000 http://www.practiceofpharmacy.com/request-information-on-toradol#comment-4 Toradol is the tradename for the non-steroidal anti-inflammatory drug (NSAID) <br /> ketorolac tromethamine.  Compared to most NSAIDs, it seems to be unusually <br /> potent as an analgesic.  It was originally made available in the US only <br /> as an injected preparation to treat post-operative pain.  More recently, <br /> oral tablets were approved for short-term use in treating mild to moderate <br /> pain. <br /> <p>Like all NSAIDs, it can cause stomach upset, and with long term use, <br /> even ulcers, which is why its use is limited to 10 days or shorter <br /> periods of time.  The drug has received a lot of interest in treating <br /> acute moderate pain because it is not a controlled substance and has <br /> no abuse potential, unlike the mainstay drugs such as Tylenol w/ Codeine <br /> or Percodan/Percocet.  On the other hand, Toradol is going to be a lot <br /> more expensive than these drugs, and the worry about abuse potential <br /> is rarely an issue for most patients. <br /> </p><p>-- <br /> Steve Dyer <br /> d...@ursa-major.spdcc.com aka {ima,harvard,rayssd,linus,m2c}!spdcc!dyer <br /> </p> Toradol is the tradename for the non-steroidal anti-inflammatory drug (NSAID)
ketorolac tromethamine.  Compared to most NSAIDs, it seems to be unusually
potent as an analgesic.  It was originally made available in the US only
as an injected preparation to treat post-operative pain.  More recently,
oral tablets were approved for short-term use in treating mild to moderate
pain.

Like all NSAIDs, it can cause stomach upset, and with long term use,
even ulcers, which is why its use is limited to 10 days or shorter
periods of time.  The drug has received a lot of interest in treating
acute moderate pain because it is not a controlled substance and has
no abuse potential, unlike the mainstay drugs such as Tylenol w/ Codeine
or Percodan/Percocet.  On the other hand, Toradol is going to be a lot
more expensive than these drugs, and the worry about abuse potential
is rarely an issue for most patients.

–
Steve Dyer
d…@ursa-major.spdcc.com aka {ima,harvard,rayssd,linus,m2c}!spdcc!dyer

]]> By: admin http://www.practiceofpharmacy.com/request-information-on-toradol/comment-page-1#comment-3 admin Thu, 13 Aug 2009 17:28:56 +0000 http://www.practiceofpharmacy.com/request-information-on-toradol#comment-3 <p>In article <GREGD.93Jul18160...@mel6.geg.mot.com> gr...@mel6.geg.mot.com (Greg Davis) writes: <br /> >Can someone please supply me with the following information on the <br /> >drug Toradol? <br /> </p><p>>  1)  What is it prescribed for? <br /> <br />Toradol is an analgesic (pain), anti-inflammatory (swelling), <br /> and antipyretic (fever) drug. <br /> </p><p>>  2)  General information <br /> <br />Toradol is a member of the NSAID family (Nonsteroidal anti- <br /> inflammatory drug). Other members include - aspirin (Bufferin <br /> et al) and ibuprofen (Motrin, Advil, Nuprin et al). <br /> </p><p>Toradol is the trade name of the drug produced by Syntex <br /> Laboratories, Inc. It's generic name is ketorolac tromethamine <br /> (usually shortened to just ketorolac). <br /> </p><p>This drug was big news when it first came out because it was the <br /> first NSAID that was as strong a pain killer as the opiates (i.e. <br /> morphine, codeine et al) but lacked the opiate side effects <br /> (mostly addiction, respiratory depression, and severe <br /> constipation). <br /> </p><p>The major draw back to Toradol is that it cannot be used for <br /> more than five days. After five days there is a marked increase <br /> in the incidence of side effects (especially renal damage). <br /> </p><p>>  3)  Cautions and warnings <br /> >  4)  Possible side effects <br /> <br />The side effects and possible contraindications for Toradol are <br /> pretty much the same as for the other NSAIDs. The incidence of <br /> side affects increases after five days of therapy and thus <br /> Toradol should not be used for more than five days. <br /> </p><p>Hypersensitivity reactions - (ie allergic reactions) especially <br /> in someone who is allergic to other NSAIDs. <br /> </p><p>Hematologic - inhibits platelet aggregation and may prolong the <br /> bleeding time. Does not appear to affect prothrombin time (PT) or <br /> partial thromboplastin time (PTT). <br /> </p><p>Gastrointestinal - ulcerations, bleeding and perforation. <br /> </p><p>Renal - events ranging from interstital nephritis to renal <br /> failure. <br /> </p><p>Other less important / less likely ones (check your PDR - <br /> Physicians' Desk Reference - or any other standard drug <br /> information book) <br /> </p><p>>  5)  Drug interactions <br /> <br />Too broad to thoroughly discuss here but the basic known <br /> interactions / altered concentrations are with; salicylates <br /> (aspirin), furosemide (Lasix), probenecid (Benemid), (The rest <br /> of the list are "maybes" - reported with some other NSAIDs, <br /> unknown if this is true with Toradol), lithium, methotrexate, and <br /> non-depolarizing muscle relaxants. <br /> </p><p>Again, check the PDR or others for a more in depth discussion. <br /> </p><p>>  6)  Food interactions <br /> <br />None that I know of. <br /> </p><p>>  7)  Usual dose <br /> <br />Again Toradol should NOT be used for more than 5 days! <br /> </p><p>Intra-muscular - A single 30 or 60 mg loading dose, followed by <br /> 15 or 30 mg every 6 hours. Maximum recommended daily dose 150 <br /> mg/day the first day, 120 mg/day thereafter. <br /> </p><p>Oral - 10 mg PRN every 4 to 6 hours. Maximum recommended daily <br /> dose 40 mg/day <br /> </p><p>>  8)  Any other information which you may have available. <br /> <br />Toradol is an excellent drug to use in patients who are <br /> experiencing temporary *severe* pain (ie < 5 days). The major <br /> group of patients who are in this group are the post - operative <br /> ones. They usually only need major pain relief for a few days and <br /> by using Toradol you can get the strength of the opiates without <br /> their side effects. This is especially important if you are <br /> worried about a patient's respiratory effort, or if they have had <br /> abdominal surgery (where you wish to avoid the straining due to <br /> constipation that can happen with opiates). <br /> </p><p>As I've said several times before, Toradol is inappropriate for <br /> long term pain relief and should not be used to treat chronic <br /> conditions. <br /> </p><p>Insert standard disclaimer here! <br /> Most of the information above is from memory with some help from <br /> the PDR 1993. Take it all with this word of caution - I am human <br /> and prone to lapses in memory, stupid mistakes and typos as we <br /> all are. If your really concerned about something check with your <br /> general practitioner (you do all have one don't you!?!?!) or <br /> whoever gave you the prescription. <br /> </p><p>Hope this all helps. <br /> Feel free to e-mail or post specific questions. I tried to the <br /> relay the information on a level that would help the layperson <br /> as well as the professional. (How'd I do?) <br /> </p><p>Darin G. Wiggins <br /> Columbia University <br /> College of Physicians and Surgeons <br /> d...@columbia.edu <br /> </p> In article <GREGD.93Jul18160…@mel6.geg.mot.com> gr…@mel6.geg.mot.com (Greg Davis) writes:
>Can someone please supply me with the following information on the
>drug Toradol?

>  1)  What is it prescribed for?

Toradol is an analgesic (pain), anti-inflammatory (swelling),
and antipyretic (fever) drug.

>  2)  General information

Toradol is a member of the NSAID family (Nonsteroidal anti-
inflammatory drug). Other members include – aspirin (Bufferin
et al) and ibuprofen (Motrin, Advil, Nuprin et al).

Toradol is the trade name of the drug produced by Syntex
Laboratories, Inc. It’s generic name is ketorolac tromethamine
(usually shortened to just ketorolac).

This drug was big news when it first came out because it was the
first NSAID that was as strong a pain killer as the opiates (i.e.
morphine, codeine et al) but lacked the opiate side effects
(mostly addiction, respiratory depression, and severe
constipation).

The major draw back to Toradol is that it cannot be used for
more than five days. After five days there is a marked increase
in the incidence of side effects (especially renal damage).

>  3)  Cautions and warnings
>  4)  Possible side effects

The side effects and possible contraindications for Toradol are
pretty much the same as for the other NSAIDs. The incidence of
side affects increases after five days of therapy and thus
Toradol should not be used for more than five days.

Hypersensitivity reactions – (ie allergic reactions) especially
in someone who is allergic to other NSAIDs.

Hematologic – inhibits platelet aggregation and may prolong the
bleeding time. Does not appear to affect prothrombin time (PT) or
partial thromboplastin time (PTT).

Gastrointestinal – ulcerations, bleeding and perforation.

Renal – events ranging from interstital nephritis to renal
failure.

Other less important / less likely ones (check your PDR –
Physicians’ Desk Reference – or any other standard drug
information book)

>  5)  Drug interactions

Too broad to thoroughly discuss here but the basic known
interactions / altered concentrations are with; salicylates
(aspirin), furosemide (Lasix), probenecid (Benemid), (The rest
of the list are "maybes" – reported with some other NSAIDs,
unknown if this is true with Toradol), lithium, methotrexate, and
non-depolarizing muscle relaxants.

Again, check the PDR or others for a more in depth discussion.

>  6)  Food interactions

None that I know of.

>  7)  Usual dose

Again Toradol should NOT be used for more than 5 days!

Intra-muscular – A single 30 or 60 mg loading dose, followed by
15 or 30 mg every 6 hours. Maximum recommended daily dose 150
mg/day the first day, 120 mg/day thereafter.

Oral – 10 mg PRN every 4 to 6 hours. Maximum recommended daily
dose 40 mg/day

>  8)  Any other information which you may have available.

Toradol is an excellent drug to use in patients who are
experiencing temporary *severe* pain (ie < 5 days). The major
group of patients who are in this group are the post – operative
ones. They usually only need major pain relief for a few days and
by using Toradol you can get the strength of the opiates without
their side effects. This is especially important if you are
worried about a patient’s respiratory effort, or if they have had
abdominal surgery (where you wish to avoid the straining due to
constipation that can happen with opiates).

As I’ve said several times before, Toradol is inappropriate for
long term pain relief and should not be used to treat chronic
conditions.

Insert standard disclaimer here!
Most of the information above is from memory with some help from
the PDR 1993. Take it all with this word of caution – I am human
and prone to lapses in memory, stupid mistakes and typos as we
all are. If your really concerned about something check with your
general practitioner (you do all have one don’t you!?!?!) or
whoever gave you the prescription.

Hope this all helps.
Feel free to e-mail or post specific questions. I tried to the
relay the information on a level that would help the layperson
as well as the professional. (How’d I do?)

Darin G. Wiggins
Columbia University
College of Physicians and Surgeons
d…@columbia.edu

]]> By: admin http://www.practiceofpharmacy.com/request-information-on-toradol/comment-page-1#comment-2 admin Thu, 13 Aug 2009 17:28:48 +0000 http://www.practiceofpharmacy.com/request-information-on-toradol#comment-2         In response to your query re: TORADOL, I was recently given a <br /> prescribed for this drug myself.  It was written by a doctor on duty at <br /> the local hospital emergency department. <br />         Indications ??  A giant HEMORRHOID (the color of purple) and the <br /> size of a golf ball!  I was told it had two properties....that of an <br /> anti-inflammatory....as well as a pain reliever.  Its pain relieving <br /> qualities were described as NON-NARCOTIC but with the approx. equivalency <br /> of a TILANOL 3 (which contains 30 mg. of codeine). <br />         I forget the dose but I was told to take 1 to 2 tabs every 4 hours (or <br /> as required).  I was to be taken with food. <br />         Possible side effects were drowsiness and upset stomach (neither <br /> of which I experienced).   <br />         I am currently taking DILANTIN and TEGRETAL which did not seem to <br /> be a problem.  Because of its stomach irritation possibilities I doubt it <br /> would be prescribed with something like TAGAMENT. <br />         I believe it is also used for arthritic pain. <br />         My G.P. had never heard of it BUT IT WORKED BEAUTIFULLY!!!! <br /> <p>:from a layman..msimm...@watserv1.uwaterloo.ca(Mike Simmons) <br /> </p>         In response to your query re: TORADOL, I was recently given a
prescribed for this drug myself.  It was written by a doctor on duty at
the local hospital emergency department.
        Indications ??  A giant HEMORRHOID (the color of purple) and the
size of a golf ball!  I was told it had two properties….that of an
anti-inflammatory….as well as a pain reliever.  Its pain relieving
qualities were described as NON-NARCOTIC but with the approx. equivalency
of a TILANOL 3 (which contains 30 mg. of codeine).
        I forget the dose but I was told to take 1 to 2 tabs every 4 hours (or
as required).  I was to be taken with food.
        Possible side effects were drowsiness and upset stomach (neither
of which I experienced).  
        I am currently taking DILANTIN and TEGRETAL which did not seem to
be a problem.  Because of its stomach irritation possibilities I doubt it
would be prescribed with something like TAGAMENT.
        I believe it is also used for arthritic pain.
        My G.P. had never heard of it BUT IT WORKED BEAUTIFULLY!!!!

:from a layman..msimm…@watserv1.uwaterloo.ca(Mike Simmons)

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